Scientific & Performance Evidence
Trudell Medical International has an enviable history of strong leadership in creating innovative medical devices that enhance the quality of life for people of all ages - all backed by science and clinical evidence.
The safety and efficacy of AEROCHAMBER PLUS* brand of chambers is validated in numerous third-party clinical evaluations with different patient populations with different MDIs.1 It is the most studied brand of spacer; supported by hundreds of in-vitro and in-vivo studies and is listed in the prescribing instructions for most MDIs.
Spacers improve lung delivery of MDIs
Relative Bioavailability of Budesonide/Glycopyrrolate/Formoterol Fumarate Metered Dose Inhaler Administered With and Without a Spacer: Results of a Phase I, Randomized, Crossover Trial in Healthy Adults
AEROCHAMBER* brand of chambers improve lung delivery by consistently delivering the intended dose, regardless of inhaler technique. A recent third-party pharmacokinetic study demonstrated that AEROCHAMBER PLUS* FLOW-VU* chamber optimizes lung delivery, even in healthy adults trained on correct technique.
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Spacers overcome coordination issues
The Impact of Inhalation Delay on Lung Drug Delivery: Using Functional Respiratory Imaging to Compare Metered Dose Inhaler (MDI) and MDI + Valved Holding Chamber (VHC) Systems
If using an MDI alone, even a short half second inhalation delay reduces the predicted lung delivery to approximately 1% of the intended dose. AEROCHAMBER® device holds the medication suspended for an extended period of time, allowing patients more time to inhale their medication.2
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Spacers reduce side effects
Assessment of Potential Mouth / Throat Deposition and Lung Delivery of Suspension- and Solution-Formulated Inhaled Corticosteroid Formulations Delivered by Pressurized Metered Dose Inhaler without and with Valved Holding Chamber Using an Anatomic Adult Upper Airway
Whether using an MDI (without a spacer) or a DPI, the majority of the dose deposits in the back of the throat.5,6 However, when combined with an MDI, the AEROCHAMBER PLUS® FLOW-VU® chamber filters out the larger particles that would deposit in the back of the throat which could lead to side-effects such as hoarseness, sore throat, or thrush.5,6 Did you know that if using the MDI alone up to 10x as much medication can deposit in the back of the throat.5
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