A laboratory assessment of nebulized medication delivery through different Oscillating Positive Expiratory Pressure (OPEP) devices - not all devices are the same

Conclusion

The results show that OPEP/Neb combination selection can have a large impact on the amount of drug delivered. The AEROBIKA * OPEP / AEROECLIPSE * breath actuated device combination delivered more than 3x as much salbutamol in a treatment compared to the other combinations. Combining OPEP and nebulizer therapy has advantages in terms of patient efficiencies, convenience, and adherence, however care should be taken to ensure the drug delivery is not compromised.