août 4, 2020

The Impact of Inhalation Delay on Lung Drug Delivery: Using Functional Respiratory Imaging (FRI) to Compare Metered Dose Inhaler (MDI) and MDI/ Valved Holding Chamber (VHC) Systems




  • Evaluations of inhaler use have demonstrated that mishandling of MDIs is commonplace.
  • One of the most common errors is the failure to coordinate inhalation with actuation of the inhaler
  • One of the reasons why VHCs are often prescribed, is to reduce the severity of this error
  • This Functional Respiratory Imaging (FRI) based study assessed the likely severity of a short inhalation delay (from actuation) with an MDI alone and how it contrasted to the use with a VHC


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