September 3, 2020

The Impact of different Valved Holding Chambers (VHCs) on Lung Drug Delivery: Using Functional Respiratory Imaging (FRI) and a single Metered Dose Inhaler (MDI) type


  • The FRI deposition profiles highlighted significant differences between the VHCs on test, with intrathoracic delivery for the AeroChamber Plus* Flow-Vu* VHC system being almost double that of the other two VHC systems and being similar to the MDI alone with perfect coordination.
  • When a short 0.5 second inhalation delay with the MDI alone was modelled, the intrathoracic lung delivery decreased from 25.4 mcg to 0.3 mcg
  • These results highlight that the use of an appropriate VHC should be considered as general practice for all MDI patients other than those with a highly proficient inhaler technique and that VHCs should not be considered interchangeable


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