• Oscillating Positive Expiratory Pressure (OPEP) devices generate positive pressure pulses in the airways.
  • By mobilizing and clearing mucus, OPEP therapy has the potential to induce changes in airways ventilation and subsequent drug deposition.
  • There is a scarcity of published evidence though linking laboratory performance characteristics to physiological effects and clinical impact.
  • A specific OPEP device is reviewed in such context in order to provide a more wholistic understanding


  • This laboratory and clinical overview demonstrates appreciable differences in pressure pulse waveforms for differing OPEP devices and then links these for the leading laboratory performing device into reported airway physiological changes and improved clinical outcomes.

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